Type 3c (Pancreatogenic) Diabetes


Type 3c diabetes (also known as Pancreatogenic diabetes) is a form of diabetes that is being researched. It involves the exocrine and digestive functions of the pancreas. Out of all the diabetics, 5–10% may actually be type 3c diabetics. In 80% of people who suffer from this condition, chronic pancreatitis seems to be the cause.

There are multiple causes. Some of which identified are:

Pancreatic disease
Pancreatic resection
Chronic pancreatitis (caused by exocrine insufficiency, maldigestion, and malnutrition).
Lacking genes in the E2F group.

Diagnostic Criteria for T3cDM
Major criteria (all must be fulfilled):

Presence of exocrine pancreatic insufficiency (according to monoclonal fecal elastase-1 or direct function tests.
Pathological pancreatic imaging: (by endoscopic ultrasound, MRI, or CT)
Absence of T1DM-associated autoimmune markers (autoantibodies).

Minor Criteria:

Imparied β-cell function
No excessive insulin resistance (e.g. as measured by HOMA-IR).
Impaired incretin (e.g. GIP) or pancreatic polypeptide secretion.
Low serum levels of lipid (fat) soluble vitamins (A, D, E, or K).