Questions How much do primary prevention strategies reduce the risk of conversion from prediabetes to diabetes, and are initial effects sustained over the long term?
Findings In this meta-analysis of randomized clinical trials including 49 029 participants, lifestyle modification and medications promoting weight loss or insulin sensitization were associated with reduced diabetes risk by 36% to 39%. Effects of medications were not sustained after they were discontinued; effects of lifestyle modification, however, were sustained after intervention was stopped, although the effects waned over time.
Meaning For individuals at risk for diabetes, healthy lifestyle changes, weight loss, or use of insulin-sensitizing medications slow the progression to diabetes similarly; lifestyle modification strategies are better in the long term, although strategies to maintain their effects are needed.
More at https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2661704?redirect=true