Diabetes Rounds

Cardiovascular Effects of Linagliptin


Question What is the effect of linagliptin compared with placebo on risk of major cardiovascular (CV) events in type 2 diabetes at high CV risk?

Findings In this randomized noninferiority trial that included 6979 patients followed up for a median 2.2 years, use of linagliptin compared with usual care resulted in an incidence of the primary composite outcome (CV death, nonfatal myocardial infarction, or nonfatal stroke) of 12.4% vs 12.1%. The hazard ratio had a 1-sided 97.5% confidence limit of 1.17, which met the criterion for noninferiority (upper confidence limit <1.3).

Meaning Among patients with type 2 diabetes and high CV risk, linagliptin, compared with placebo, demonstrated noninferiority with regard to risk of major CV events over a median of 2.2 years.

More at https://jamanetwork.com/journals/jama/article-abstract/2714646